Oxytocin receptors on oxytocin neurones: histoautoradiographic detection in the lactating rat.
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چکیده
منابع مشابه
Presence of oxytocin receptors in the gonadotrophin-releasing hormone (GnRH) neurones in female rats: a possible direct action of oxytocin on GnRH neurones.
Gonadotrophin-releasing hormone (GnRH) neurones constitute the final output pathway of a neuronal network that controls the preovulatory luteinising hormone (LH) surge and ovulation. Throughout the reproductive cycle, several neurotransmitters stimulate and inhibit the activity of GnRH neurones, including oxytocin. The central administration of oxytocin antiserum abolishes the pro-oestrous LH s...
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Lactation is a physiological condition known to upregulate the expression of the hypothalamic neurohormones, oxytocin and vasopressin, in the rat supraoptic and paraventricular nuclei. Other neuropeptides such as galanin are co-localized in the same magnocellular neurones and their expression has been demonstrated to be regulated by different experimental and physiological conditions. In the pr...
متن کاملLoss of myometrial oxytocin receptors during oxytocin-induced and oxytocin-augmented labour.
Oxytocin is used widely for the induction and augmentation of labour, but there is little information about the dynamics of oxytocin receptors in human myometrium during parturition, and the possible effect of oxytocin infusion. This information is important because G protein-coupled receptors, such as the oxytocin receptor, undergo desensitization after prolonged or repeated stimulation. The c...
متن کاملThe Role of Exogenous Oxytocin in Lactating Ewe
The effect of exogenous oxytocin on milk yield is studied in a series of experiments on the dairy ewe. Experiments I and II. A non-galactokinetic dose (o.oi and 0.5 IU/hr) injected into the carotid artery did not change milk yield. The results do not seem to confirm central oxytocin action on the lactogenic hormonal complex of the hypophysis. Experiments III, IV, V. IV injection of oxytocin (0....
متن کاملOxytocinase in the female rat hypothalamus: a novel mechanism controlling oxytocin neurones during lactation.
In addition to its peripheral actions, oxytocin released within the brain is important for birth and essential for milk ejection. The oxytocinase enzyme (placental leucine aminopeptidase; P-LAP) is expressed both peripherally and centrally. P-LAP controls oxytocin degradation in the uterus, placenta and plasma during pregnancy, although its role in the hypothalamus is unclear. We investigated P...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1994
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1994.sp020349